Clinical Trials in Cardiology - B


Maintained by Dr. Olga Shindler. Last update on February 20, 2001.

Alphabetic list:
A / B / C / D / E / F / G / H / I / J / K / L / M /
N / O / P / Q / R / S / T / U / V / W / X / Y / Z /


BAAS
Balloon Angioplasty and Anticoagulation Study


BAATAF
Boston Area Anticoagulation Trial for Atrial Fibrillation
(a) N Engl J Med 1990;323:1505-11
(b) Am Heart J 1992;124:1567-73
(c) Stroke 1993;24:1360-5


BAHS
Boston Area Health Study


BANFF
Brachial Artery ultrasound Normalization of Forearm Flow

A Comparative Study of Four Anti-hypertensive Agents on Endothelial Function in Patients With Coronary Disease T.J. Anderson1, R.W. Overhiser, H. Haber, F. Charbonneau

Background: Quinapril, an ACE inhibitor with high affinity, has been shown to improve coronary endothelial dysfunction in patients with CAD. The effectiveness of different vasoactive agents to improve human endothelial function is unknown. In the BANFF study, we used high resolution ultrasound to compare the chronic effects of four anti-hypertensives on brachial artery flow-mediated vasodilation (FMD) in patients with documented CAD. Methods: Patients were enrolled in a partial-block, cross-over design trial, and randomized in one of four different, open label drug sequences. The core ultrasound lab and data analysis center were masked to treatment. FMD and NTG-induced dilation were evaluated before and after 8 weeks of each study drug. Two week washout was imposed between treatments.
Results: CAD patients had significantly impaired FMD (6.2 0.6%, n = 80) compared to normals (10.9 0.8%, N = 40, p < 0.05). Absolute changes in FMD from baseline are shown below.

 
Drug	         N	 Change FMD (Mean  SE)	   p value 
Quinapril 20 mg	 56	 1.8  1.0%	           <0.02 
Enalapril 10 mg	 55	 -0.2  0.8%	           0.84 
Losartan  50 mg	 38	 0.8  1.1%	           0.57 
Amlodipine 5 mg	 45	 0.3  0.9%	           0.97 

No significant differences in NTG-induced dilation were observed.
Conclusion: Only quinapril was associated with significant improvement in flow-mediated dilation. ACE inhibitors may differ in their ability to improve vascular endothelial function.


BARI
Bypass Angioplasty Revascularization Investigation
Eur Heart J 1989;10(suppl H):85-91
(c) N Engl J Med 1996;335:217-225
(b) Circulation 1997;96:1761-79
(c) N Engl J Med 1997;336:92-99
(a) JAMA 1997;277:715-721


BARI Substudy
Bypass Angioplasty Revascularization Investigation
Circulation 1998;98:1279-1285


BARI (7 year outcome - Diabetics)
Bypass Angioplasty Revascularization Investigation
J Am Coll Cardiol 2000;35:1122-1129


BAROCCO
Balloon Angioplasty vs ROtacs for total Chronic Coronary Occluson trial


BAS
Bronx Aging Study


BASE
Berlin Aging Study


BASIS
Basal Antiarrhythmic Study of Infarct Survival
(a) J Am Coll Cardiol 1990;16:1711-1718
(b) Am J Cardiol 1992;69:1399-402
(c) Schweiz Med Wochenschr 1993;123:533-6
(d) Circulation 1993;87:309-311


BBB
Behandia Blodtryck Battre study ("Treat Blood Pressure Better")
(a) J Hypertens 1988;6:693-7
(b) Blood Press 1994;3:248-254


BBPP
Beta Blocker Pooling Project
Eur Heart J 1988;9:8-16


BCAPS
European Atherosclerosis Society, 1996:109


BCIS
British Cardiovascular Intervention Society


BCSP
Bavarian Cholesterol Screening Project


BECAIT
Bezafibrate Coronary Atherosclerosis Intervention Trial
(a) Lancet 1996;347:849-53
(b) J Am Coll Cardiol 1998;32:1648-1656


BELLES
Beyond Endorsed Lipid Levels Evaluation Study


BENESTENT
BElgian NEtherlands STENT study
(a) N Engl J Med 1994;331:489-495 (b) J Am Coll Cardiol 1996;27:255-61


BENESTENT II
BElgian NEtherlands STENT II study
(a) Circulation 1996;93:412-22
(b) Lancet 1998;352:673-681


BENIR
BElgian NIR stent trial examines the value of coronary stenting (with the NIR stent) for the prevention of restenosis in patients with a suboptimal coronary angioplasty results (residual stenosis after on-line QCA controlled PTCA >30% and < 50% diameter stenosis). Six cardiological centers within Belgium are participating in this trial.
Information provided by: Prof dr C Vrints
University Hospital of Antwerp
Dept of Cardiology
Wilrijkstraat 10 B2520 Edegem
phone: 32-3-8213005
fax: 32-3-8250848
email: vrints@uia.ua.ac.be


BEPS
Belgian Eminase Prehospital Study
Eur Heart J 1991;12:965-7


BERCI-I
BERaprost et Claudication Intermittenti


BE SMART
BEStent in Small ARTeries


BEST
Beta-blocker Evaluation of Survival Trial
Bucindolol Evaluation of Survival Trial
Am J Cardiol 1995;75:1220-3
NEJM editorial
Beta blockers in heart failure.


BEST
BEta-blocker Stroke Trial
BMJ 1988;296:737-41


BEST
Bolus dose-Escalation Study of Tissue-type plasminogen activator


BGPS
Belgian General Practitioners' Study


BHAT
Beta-blocker Heart Attack Trial
(a) JAMA 1982;247:1707-14
(b) JAMA 1983;250:2814-9
(c) Ann Intern Med 1993;118:99-105


BHFS
Benazepril Heart Failure Study


BHS
Bogalusa Heart Study


BIG-MAC
Beaumont Interventional Group-Mevacor, ACE inhibitor, Colchicine restenosis trial


BIG-MAC
Bidirectional Gantry Multi-Array Coil study


BIGPRO
BiGuanides and the Prevention of the Risk of Obesity study


BIOMACS II
Biochemical Markers in Acute Coronary Syndromes
J Am Coll Cardiol 1999;33:627-633


BIP
Bezafibrate Infarction Prevention study
(a) Am J Cardiol 1993;71:909-15
(b) J Clin Epidemiol 1995;48:757-65
(c) Eur Heart J 1999;20:7-10


BIRD
Bolus vs Infusion Rescupase Development
Eur Heart J 1999;20:7-10


BIRNH
Belgian Interuniversity Research on Nutrition and Health study


BLAS
Bronx Longitudinal Aging Study


BLASP
Barbados Low-dose Aspirin Study in Pregnancy


BLSA
Baltimore Longitudinal Study of Aging


BMRC
British Medical Research Council trial of the effect of aspirin in postoperative deep venous thrombosis


BMS
Belfast Metoprolol Study


BNS
Belfast Nifedipine Study


BOAS
Bank Of America Study of retiree population


BOAT
Balloon vs Optimal Atherectomy Trial
Circulation 1998;97:322-331


Bogalusa Heart Study
Ann NY Acad Sci 1997;817:189-98


BOILER
Balloon Occlusive Intravascular Lysis Enhanced Recanalization strategy


BPEG
British Pacing and Electrophysiology Group study


BPSMC
Blood Pressure Study in Mexican Children


BRAINS
Biochemical Research And INformation Study


BRAVO
Blockade of the GP IIB/IIIA Receptor to Avoid Vascular Occlusion


BRCT
Brain Resuscitation Clinical Trial


BRESUS
British hospital RESUScitation study


BRFSS
Behavioral Risk Factor Surveillance System


BRH
British Regional Heart study


BRHS
British Regional Heart Study


BRILLIANT
Blood pressure,Renal effects,Insulin control,Lipids,LIsinopril And Nifedipine Trial


BUPA
British United Provident Association study


BVR
Balloon Valvuloplasty Registry


BWIS
Baltimore Washington Infant Study

Alphabetic list:
A / B / C / D / E / F / G / H / I / J / K / L / M /
N / O / P / Q / R / S / T / U / V / W / X / Y / Z /


e-mail:shindler@umdnj.edu
Copyright © 1995-2001 Dr. Olga Shindler.